Neurotransmitter Transporters: Structure Meets Function
نویسندگان
چکیده
منابع مشابه
SLC6 neurotransmitter transporters: structure, function, and regulation.
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene family (also referred to as the neurotransmitter-sodium-symporter family or Na(+)/Cl(-)-dependent transporters) comprise a group of nine sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino ...
متن کاملStructure, function and brain localization of neurotransmitter transporters.
We studied four different cDNAs encoding GABA transporters and three different cDNAs encoding glycine transporters in mouse and rat brains. A genomic clone of two of the glycine transporters (GLYT1a and GLYT1b) revealed that they derive from differential splicing of a single gene. The third glycine transporter (GLYT2) is encoded by a separate gene. Antibodies were raised against seven of these ...
متن کاملNeurotransmitter Transporters
Neurotransmitters are released into the extracellular space during synaptic transmission. The actions of these chemical signals are terminated through active uptake by transporters that are located in the plasma membrane of neurons and glial cells. Transporters harness electrochemical gradients to force the movement of transmitter back into cells against its concentration gradient. These protei...
متن کاملWhere Structure Meets Function
5-Hydroxytryptamine 2 (serotonin 2 , 5-HT 2 )-family receptors are important for mediating many physiological functions, including vascular and nonvascular smooth muscle contraction, platelet aggregation, modulation of perception, mood, anxiety, and feeding behavior. A large number of psychopharmaceuticals, including atypical antipsychotic drugs, antidepressants, anxiolytics, and hallucinogens,...
متن کاملPorters and neurotransmitter transporters.
Uptake of neurotransmitters involves multiple transporters acting in different brain locations under different physiological conditions. The vesicular transporters are driven by a proton-motive force generated by a V-ATPase and their substrates are taken up via proton/substrate exchange. The plasma membrane transporters are driven by an electrochemical gradient of sodium generated by a Na+/K(+)...
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ژورنال
عنوان ژورنال: Structure
سال: 2013
ISSN: 0969-2126
DOI: 10.1016/j.str.2013.03.002